VU Final Term Past Papers
98 solved final term past paper MCQs for BIF401 (Bioinformatics-I) at Virtual University, each with the correct answer marked. Use them to learn the VU question style and test your recall. An independent study tool — not affiliated with VU.
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Q1. In mass electrometer chamber protein is deflected according to its _____
Q2. while scoring protein mass score is awarded on the base of _____.. b/w experimental and theoretical mass.
Q3. Tandem MS is used to _____ of protein fragments.
Q4. Tandem MS is typically called as,
Q5. Each fragmentation technique differ in their work on bases of ,
Q6. Protien ionization is the _____ step in MS based proteomics.
Q7. molecular weight increases by _____. Of proton
Q8. We can score each protein hit in away that the better match gets a _____
Q9. ECD gives out “C” and _____.. ions,
Q10. CID gives out “B” and _____.. ions,
Q11. PST is abbreviation of_____..
Q12. PST is sequence of peptidesproduced during_____..
Q13. Fragmentation at consecutive sits lead to a mass difference equal to that of a single _____..
Q14. The data base protein which have matching PSTs to invitro protein are known as _____
Q15. Errors in peak matching also considered by_____.
Q16. large scale proteomics is a developed form of
Q17. Mass spectrometry use to measure _____. Ratio of ionized protein or peptide.
Q18. Raw file in a format are often found in _____. That we have to change in an open format so as to make it readable.
Q19. mzData was developed by _____
Q20. MASCOT is an online _____. Search engine,
Q21. _____.. is a simple human readable format for MS/MS developed by Matrix Science.
Q22. To ensure that all fragments of precursor molecules are also charged, we can use,
Q23. Monoisotopic mass is the mass of _____..
Q24. Tendem MS helps to measure the moleculer weight of _____
Q25. Amno acid with the side chain containing organic acids are soluble in _____.
Q26. _____.. residue has no R group.
Q27. proline residue _____ the flexibility of polypeptide chain.
Q28. A peptide unit has a backbone of polar NH and C=O which is highly_____..
Q29. The force involve in protein folding _____
Q30. _____folded form of protein is thermodynamically more stable than others.
Q31. 3´ structural can combine with other polypeptide units to form _____.
Q32. There is a _____ variety of protein structure exist.
Q33. Folded sub structures are called _____.
Q34. Lysine and tryptophan have respectively _____.. 1-letter codes.
Q35. C- terminus is _____ charge.
Q36. _____ bonds are the reason of 2’ structure formation.
Q37. Loops and Coils are very important 2’ structures in that they form _____ of proteins.
Q38. _____.. Enforce the 3’ structure.
Q39. Proteins with _____. chain can form 4’ structures.
Q40. Dihedral Angles always form between _____
Q41. _____. angles are taken up as a result of folding of protein.
Q42. Atoms of phosphorus,sulfur, and chlorine are _____ in covalent radius.
Q43. The angstrom is used to express _____
Q44. Distances between C-Alphas are measured in the unit “Angstrom” by the process of .._____..
Q45. 1 A resolution is better than _____..
Q46. PDB contains protein _____ information
Q47. PyMOL and Cn3D is a python-script based tool for visualizing the _____..
Q48. BS Models have atoms as colored balls and intermediate bonds as _____..
Q49. In CPK diagrams, each atom is represented by a _____..
Q50. According to “Anfinsen’s thermodynamic hypothesis” protein folds for making a _____..
Q51. To determine the number of each type of interaction within a protein, we need to find its _____
Q52. By looking up at the bond/energy table, we can compute the _____.
Q53. “Helix Formers” are generally_____.. amino acids (M, A, L_____)
Q54. Alpha Helices are formed by hydrogen bonding (O-H)between _____ and _____. atoms in the protein backbone
Q55. _____ resides are needed to make a Beta Strand,typically
Q56. what is made by a single beta sheet when it twists and coils upon itself.
Q57. _____ are apparently disordered regions with random structure and random length.
Q58. The structural classes of Domains can be further classified into _____
Q59. Architecture also called _____..
Q60. _____.. is one such system in which proteins are organized into classes, architecture, topology & homology.
Q61. For comparing the complete or partial protein structures, the position of _____. can be used.
Q62. Whole protein structures can be compared by calculating the _____..difference b/w their Alpha Carbons positions.
Q63. The _____. the RMSD, the similar are the proteins.
Q64. RMSD tells us about the quality of the matches
Q65. For Alpha Helices _____.. contiguous amino acids are required.
Q66. Alpha-Helix propensity should be more than _____. Once this propensity falls, Alpha- Helix stops.
Q67. In chou fasman algorithm Alpha Helices can be finalized if their propensity is _____. to the propensity for Beta Sheets.
Q68. Chou Fasman Algorithm helps us to predict,
Q69. Beta sheets can be predicted from _____ amino acid sequences
Q70. Chou Fasman Algorithm is based on statistical occurrence of _____. in known structures.
Q71. Functional evaluation of proteins can be performed by_____
Q72. Functional evaluation of proteins is important for understanding _____.
Q73. X-Ray Crystallography and NMR Spectroscopy are used to find the structures of _____..
Q74. it is then possible to identify unknown protein structures by just examining the _____.. protein sequences
Q75. In homology modelling, proteins with similar _____.. are considered.
Q76. Protein structure can be predicted by_____ methods:
Q77. in homo logy modeling,Definition of Template (_____..) & Target (_____)
Q78. One way to handle loops is to take some residues before and after the insertion as _____.. residues.
Q79. Homology Modelling _____.. study conformational changes.
Q80. We can overcome the limitations of homology modeling by _____..
Q81. Several tools are available to perform homology modelling in a programmatic or automated way such as_____..
Q82. Fold recognition is also called _____.
Q83. Threading Scoring typically involves using a _____.. function based on energy of a molecule
Q84. _____ cannot be predicted using threading.
Q85. 3D-1D methods convert structure and environment information into _____..
Q86. Ab initio modeling is Computationally _____. Suitable for proteins with less than _____ residues
Q87. Ab Initio Modelling methods attempt to identify the structure with minimum _____.
Q88. Energy released during the _____.. process is computed for predicting structure.
Q89. Global optimization finds the most _____.
Q90. _____structure not always at the global minimum.
Q91. Ab initio methods are the very _____.. to design.
Q92. In homology modeling first we perform _____. and then _____..
Q93. Ab initio modeling is Computationally _____. And _____ process.
Q94. UPGMA is a _____ method.
Q95. Homology modelling is performed in cases of _____ identity and alignment score • For the “Twilight zone”, other strategies are employed
Q96. Maximum Parsimony etc are_____. methods (not included in this course).
Q97. Online tools: _____..
Q98. Number of known protein sequences is _____.. as compared to known proteins structures